Topic: CRH

Experiencing traumatic events can lead to the development of posttraumatic stress disorder (PTSD) in susceptible individuals. Pinpointing risk factors and mechanisms that lower individual vulnerability to PTSD presents a significant clinical challenge with considerable promise in prevention and threapy. Here we aimed to identify pretrauma cognitive and emotional traits and their neurobiological correlates that predict posttrauma fear generalization, a core symptom of PTSD. An unbiased exploration of neurobehavioral vulnerability traits determining trauma-related fear generalization suggests pr

Post-traumatic stress disorder (PTSD) is a multifaceted psychological disorder characterized by deregulated fear and stress responses. Etiology and progression of PTSD involve multiple neurochemical factors that interact in complex ways and consequently alter range of neurotransmitters systems. One of the most important is CRH system, which involvement in fear and stress response is well established. CRH acts through two receptors, CRHR1 that plays role in stress responding and anxious arousal and CRHR2 that is responsible for dampening the stress response initiated by activation of CRHR1. In