Topic: CRH receptor 1

The corticotropin-releasing hormone (CRH) is a peptide associated with stress and anxiety that acts as a potent modulator in the central nervous system. The thalamic reticular nucleus (TRN) displays high expression of the CRH receptor 1 (CRHR1), but whether CRH modulates key TRN functions, such as sleep spindle rhythmogenesis, has not yet been explored.Using viral mapping, we identified diverse extra-hypothalamic CRH afferents to the TRN, such as the basolateral amygdala, zona incerta and subnuclei within the geniculate nucleus. Combining polysomnographic and photometric recordings in mice, we

Corticotropin-Releasing Hormone (CRH) was first identified as a neurohormone secreted by the hypothalamus in response to stressful stimuli. However, large amounts of CRH are also secreted by the placenta of anthropoid primates during pregnancy. Although the role of hypothalamic CRH has been extensively studied, there is a remarkable lack of evidence regarding the role of placental CRH, while the biological significance of its unique expression pattern in anthropoid primates remains elusive. In order to investigate the effects of placental CRH on human brain development and to overcome the limi