Topic: CRHR1

Post-traumatic stress disorder (PTSD) is a multifaceted psychological disorder characterized by deregulated fear and stress responses. Etiology and progression of PTSD involve multiple neurochemical factors that interact in complex ways and consequently alter range of neurotransmitters systems. One of the most important is CRH system, which involvement in fear and stress response is well established. CRH acts through two receptors, CRHR1 that plays role in stress responding and anxious arousal and CRHR2 that is responsible for dampening the stress response initiated by activation of CRHR1. In

The ketogenic diet (KD) is known to reduce ethanol consumption in non-stress conditions (Blanco-Gandía et al. 2021). Therefore, our objective was to assess whether KD modifies stress-induced changes in gene expression and ethanol consumption in female mice. 64 female OF1 mice were categorized into four groups based on the administered diet (KD vs. Standard Diet, STD) and exposure to stress (Vicarious Social Defeat sessions, VSD, vs. Exploration sessions, EXP): STD-EXP (n=16), STD-VSD (n=16), KD-EXP (n=16), and KD-VSD (n=16). The KD-fed mice remained in ketosis from adolescence until the final

Early-life stress (ELS) disrupts brain development and predisposes sufferers to stress-related disorders and compulsive behaviour in adulthood. Accumulating evidence connects these disorders with neurons within the stress-sensitive, brainstem nucleus incertus (NI), which synthesize the neuropeptides, relaxin-3 (RLN3) and cholecystokinin (CCK). Although NI RLN3 neurons are implicated in stress responses, arousal and drug-seeking behaviour, their vulnerability to stress during development has not been explored, and little is known about NI CCK neurons. Therefore, this study investigated the infl