Topic: Cross-frequency coupling

An open problem in neuroscience is to explain the functional role of oscillations in neural networks, contributing, for example, to perception, attention, and memory. Cross-frequency coupling (CFC) is associated with information integration across populations of neurons [1]. Impaired CFC is linked to neurological disease [2]. It is unclear what role CFC has in information processing and brain functional connectivity. We construct a model of CFC which predicts a computational role for observed $\theta - \gamma$ oscillatory circuits in the hippocampus and cortex [3]. Our model predicts that the

Having a patient specific mapping of the eloquent cortex is crucial for patients undergoing resective surgery. Non-invasive neuroimaging modalities like magnetoencephalography (MEG) are increasingly used for pre-surgical mapping due to high temporal resolution. Phase-amplitude coupling (PAC), a form of cross-frequency coupling, involves the modulation of high-frequency amplitude by the phase of low-frequency oscillations. PAC observed during tasks reflect interactions between microscale and macroscale neural ensembles. The objective of this study was characterizing whether PAC differs during t

The transition from externally to internally focused attention is accompanied by the coactivation of a group of brain regions collectively known as the default mode network (DMN). While the DMN was initially considered as a cortical network, recent results have provided evidence that some subcortical structures are also involved in DMN regulation. Here we investigated the subcortical nodes, ventral pallidum (VP) and mediodorsal thalamus (MD), in DMN regulation in the tree shrew, a diurnal mammal that is a close relative of primates. We use wireless multichannel recordings and motion tracking,