Cultured cortical neurons

…with brain-like properties in a cultured environment, has attracted attention for investigating the relationship between connection structure and activity patterns. As fundamental technologies for realizing such devices, bioengineering technologies to reconstruct modular structure and directional connection with living cells have been developed previously, they have not been integrated to realize modular networks with directionality. In this study, we developed a novel microfluidic device to reconstruct such network with cultured c

…In vitro cultured cortical neurons have been used extensively as a realistic experimental tool to understand the underlying mechanisms in neuronal assemblies. One of the main characteristics of the activity of such networks are the spontaneous synchro