Topic: current-source density analysis

We used dense (20 m site spacing) local field potential (LFP) and single unit recordings across all layers of the gRSC concurrent with CA1 LFP recordings in behaving mice to investigate circuit activity of high-frequency oscillations (HFOs) in theta and sharp wave-ripples (SWRs). By comparing HFOs occurring at times of SWRs (+/-50 ms) or during theta, we found using current-source density analysis that HFOs in different states are uniformly localized to layer 2/3 (L2/3) with current sources and sinks bridging the L1-L2/3 border. HFOs that occurred outside of SWR times where rhythmically locke