Current source density analysis

Mammals evolved a highly structured neocortex, composed of six cellular layers that are organized in functional columns. At first sight, the avian forebrain lacks a structured neocortex. However, the microstructural level of the avian sensory forebrain exhibits remarkable anatomical similarities to the mammalian brain organization. This study focuses on investigating the functional properties of three avian visual forebrain structures, to determine whether both taxa share a common functional neural circuitry, despite apparent anatomical differences. We conducted multi-channel electrophysiologi

…across all layers of the gRSC concurrent with CA1 LFP recordings in behaving mice to investigate circuit activity of high-frequency oscillations (HFOs) in theta and sharp wave-ripples (SWRs). By comparing HFOs occurring at times of SWRs (+/-50 ms) or during theta, we found using current-source density analysis that HFOs in different states are uniformly localized to layer 2/3 (L2/3) with current sources and sinks bridging the L1-L2/3 border. HFOs that occurred outside of SWR times where rhythmically locke