Investigating the efficiency of a mitochondria booster to improve anxiety-related behaviors: Accumbal metabolic and neurobiological mechanisms
David Mallet, Doğukan Hazar Ülgen, Simone Astori, Jocelyn Grosse, Isabelle Guillot de Suduiraut, Olivia Zanoletti, Carmen Sandi · FENS Forum 2024
Background: Emerging evidence suggests a central role of mitochondria in psychiatric disorders. We have previously shown that high anxious (HA) rats exhibit reduced active coping behavior under adversity and competitiveness. HA animals also show alterations in the neural circuits involved in motivation such as nucleus accumbens (Nac), at both the cellular and organelle level. We have identified an essential role for mitochondria and energy metabolism in NAc function in effort-related and motivated behaviors, suggesting that boosting mitochondrial function in the NAc could lead to enhanced perf
ePoster · Neuroscience