Topic: dCA1

Understanding the mechanisms of statistical learning, where organisms infer structure from sensory observations without explicit instruction, is crucial in comprehending how the brain processes and responds to complex environments. This work explores the innate capabilities of both humans and mice to discern environmental regularities, focusing on the role of the hippocampus in this implicit learning processes. We use pupillometry to measure whether animals can detect and track patterns in rapidly unfolding sounds. The study leverages a novel comparative behavioural paradigm, termed X-detectio

Most aspects of animal behavior are based on decisions. One of the most extensively researched type of decisions is spatial choice -that uses spatial information to suppress inappropriate behaviors (Bannerman et al. 2012). The population activity of place cells in the dCA1 area underlies spatial choice and memory. Place cell activity can be recorded when an animal is freely moving throughout the space. However, in the majority of studies on spatial choices, behavior is investigated with protocols that require direct involvement of the researcher. Additionally, traditional tools used for assess

It is widely believed that synaptic transmission in the hippocampus plays a crucial role in formation of contextual memories. Data obtained in our laboratory implies that PSD-95 (postsynaptic density protein 95)-dependent synaptic plasticity in dCA1 area is required for updating of contextual fear memory.To check how inactivation of dCA1 area affects contextual fear memory extinction, we stereotactically injected the adenoviral vectors (AAVs) encoding DREADD receptor hM4 [AAV2.1:hSyn_hM4_mCherry]. Next we trained mice in contextual fear conditioning (CFC). We found that chemogenetic inhibition