Topic: decoding analyses

Spatial cognition depends on an accurate representation of orientation within an environment. Head direction cells in distributed brain regions receive a range of sensory inputs, including proprioceptive, vestibular, and somatosensory information, but visual input is particularly important for aligning their responses to environmental landmarks. To investigate how population-level heading responses are aligned to visual input, we recorded from the retrosplenial cortex (RSC) of head-fixed mice in a moving environment using two-photon calcium imaging. RSC receives strong inputs from both visual

Previous neuroanatomical tracing studies on monkey ventrolateral prefrontal cortex (VLPFC) suggest the existence of a rostro-caudal organization, in which caudal and middle areas are mainly involved in controlling oculomotor and skeletomotor behaviors, respectively, while rostral ones in more abstract operations (Gerbella et al. 2017). A recent study (Rozzi et al. 2023) demonstrated that this region, as a whole, processes contextual information relevant for action guidance. To address whether there are potential functional differences within specific VLPFC areas, we employed Demixed Principal