Topic: delta-9-tetrahydrocannabinol

Consumption of cannabinoid-containing products has increased for their beneficial effects on pregnancy for reducing symptoms such as nausea, vomiting or anxiety. However, FDA clearly strongly advises against the use of delta-9-tetrahydrocannabinol (THC) during pregnancy. Alongside, mostly of the studies have investigated the effects of prenatal THC (pTHC) exposure, in males only, but pTHC shows a sex bias. Here, we investigate the effects of pTHC exposure in the male and female young rats.Sprague and Dawley rats were subcutaneously treated with THC (2 mg/kg/day) or vehicle (VHC), from gestatio

Cannabis is among the most used illicit substances in the world, and it is estimated that around 10% of regular cannabis users are susceptible to developing cannabis use disorder (CUD). Our study aimed to clarify the effect of delta-9-tetrahydrocannabinol (THC) on epigenetic DNA modifiers conducting DNA methylation and demethylation (DNMTs and TET enzymes) on human peripheral mononuclear cells (PBMCs) in vitro. Additionally, we profiled the genome-wide effect of THC and assessed if any genes with marked changes in methylation or hydroxymethylation could be identified. Changes in DNA methylatio