Dendritic branching

Hermann Cuntz discusses computational explanations of dendritic branching and the construction of synthetic neuronal morphologies.

…A749G mutation induced an overall dendritic spine elongation in transfected mouse hippocampal neurons. This study aimed to investigate the influence of A749G Cav1.3 channels on the dendritic branching, spine density, and neuronal soma size in the brains of heterozygous (HET) A749G knock-in mice. To do

Dendritic branching mechanisms are precisely controlled during brain development, as dendritic architecture provides the specificity and capacity of the synaptic input. Integrin receptors on the neuronal membrane are critical regulators of when and where the dendritic arborization will take place during neuronal differentiation. Integrin activity is not solely dictated by external ligand binding – the receptor's shape and function are also fine-tuned by intracellular binding proteins, including actin-binding protein Filamin A (FlnA). By combining in vitro mouse neuronal cultures with genetic a