Topic: dendritic complexity

The size and structure of the dendritic arbor play important roles in determining how synaptic inputs of neurons are converted to action potential output and how neurons are integrated in the surrounding neuronal network. Accordingly, neurons with aberrant morphology have been associated with neurological disorders. Dysmorphic, enlarged neurons are, for example, a hallmark of focal epileptogenic lesions like focal cortical dysplasia (FCDIIb) and gangliogliomas (GG). However, the regulatory mechanisms governing the development of dendrites are insufficiently understood. The evolutionary conserv

Cognitive processing requires directed interactions between several brain areas of the limbic system, such as the hippocampus (HP) and lateral entorhinal cortex (LEC). They are modulated by multiple sensory systems. During development, the olfactory system might have a particular impact on these areas in mice that at birth are blind, deaf, do not whisker and have poor motor abilities. We previously showed that neonatal olfactory activation boosts the oscillatory entrainment of LEC via mono-and polysynaptic projections from the olfactory bulb (OB). However, the long-lasting impact of olfactory