Topic: dendritic mRNA

Neurons use a variety of strategies, including local protein synthesis and pre-established protein pools inside dendrites, to maintain the dynamic proteome requirements for appropriate synaptic activity. While certain proteins have local mRNA that allows for on-demand synthesis at the synapse, the vast majority do not. This poses an important question: how can these proteins manage their copy number without boosting the synthesis rate locally? This study looks into the hypothesis that the amount of the protein pool in dendrites corresponds with the presence or lack of dendritic mRNA for local