Topic: dentate gyrus granule cells

Noradrenaline is released via volume transmission from axons originating in the locus coeruleus and released into the parenchyma to be detected by both neurons and astrocytes. Noradrenergic α-1 receptors are Gq-coupled receptors that induce intracellular calcium release from the endoplasmic reticulum as a key pathway for astrocyte calcium signalling. Due to interactions between astrocytes and synapses including their known roles in structural isolation of synapses, metabolic support, potassium buffering and gliotransmitter release, fluctuations of intracellular calcium in astrocytes can influe

Upstream regulators on the c-Jun amino-terminal kinase (JNK) pathway are associated with neuropsychiatric disorders such as schizophrenia, bipolar, and autism. However, the mechanism of action of the JNK pathway in the context of these diseases is unknown. We previously identified that inhibition of JNK in dentate gyrus granule cells of mouse hippocampus induces a low anxiety- and low depressive-like phenotype (Mohammad et al., Molecular Psychiatry, 2018). However, whether JNK pathway activity in other brain regions contributes to these behaviours is not known. Here we use cell restrictive exp

Excessive alcohol consumption during adolescence is regarded as a risk factor for the development of alcoholism later in life, but the pathophysiological mechanisms that render the adult brain susceptible to alcohol are largely unknown. GABAA receptors are among the targets of alcohol to regulate neural activity in the brain. Work from our lab has demonstrated that activin, a member of the TGF-β family, controls alcohol potentiation of GABAA receptors in adult mouse dorsal hippocampus. Considering the well-known functional segregation along the hippocampal longitudinal axis, we examined here h