Depression-like behavior

…Mice also show depression-like behavior following social stress, and the extent of behavioral changes are variable among individuals even under a uniform genetic background. The precise mechanisms that underlie variability in stress resilience among individuals are poorly understood. To elucidate the mechanisms, we focused on the long-term effects of repeated social defeat stress (SDS) in B

Chronic atopic dermatitis (AD) affects millions globally and has an alarming propensity to generate comorbid chronic depression. Currently, no effective therapies exist specifically for AD-generated comorbid depression (ADCD), likely due to unknown itch- and affect-processing brain mechanisms and inadequate preclinical models. Hence, there is a critical need for a suitable pre-clinical research model that can be used to study ADCD’s unique pathophysiology. In this investigation, we searched for preclinical models of ADCD by evaluating previously established house dust mite-induced (HDM model)

Major depressive disorder (MDD) is a great challenge for psychiatry with up to 40% of treatment-resistant patients. Therefore, non-pharmacological interventions such as different diets seem a promising tool. Ketogenic diet (KD) is a powerful tool for epilepsy and metabolic diseases while new clinical and animal studies show also its potential against mental disorders such as MDD, bipolar disorders and schizophrenia. Several neurobiological pathways have been suggested to mediate effect of KD for the brain and mental health with neurotrophic and neuroplasticity factor BDNF among them. Therefore

…we present the GM composition and depression-like behavior in Hualpha-Syn(A53T) transgenic mice, line G2-3, which over-express human α-synuclein and are the only model of PD that exhibits prodromal constipation. Additionally, we investigated whether sharing social microenvironmen