Depressive-like phenotype induced by AAV-mediated overexpression of human α-synuclein in midbrain dopaminergic neurons
Laura Kondrataviciute, Minesh Kapadia, Jimmy George, Hien Chau, Erdost Yildiz, Taufik Valiante, Luka Milosevic, Lorraine V. Kalia, Suneil K. Kalia · FENS Forum 2024
Parkinson's disease (PD), as the most prevalent neurodegenerative motor disorder, presents a complex spectrum of symptoms encompassing both motor impairments (bradykinesia, resting tremor, freezing of gait) and non-motor manifestations (depression, anosmia, anxiety). Robust animal models that faithfully replicate this multifaceted pathology are indispensable for comprehensive PD research. This study aims to investigate if depressive-like behaviour, prominent in up to 40% of PD patients (Laux, 2022), emerges in the bilateral human mutated alpha-synuclein (A53T) rat model of PD.40 adult Sprague-