Topic: depressive-like behaviors

The basolateral amygdala (BLA) is increasingly recognized as a key regulator of depression and anxiety-like behaviors. However, the specific contribution of individual BLA neurons to these behaviors remains poorly understood. Building on our previous study, which demonstrated increased activity in glutamatergic BLA neurons in response to aversive stimuli and that enhancing inhibition in the BLA can alleviate depressive-like behaviors, we investigated the role of individual GABAergic neurons (BLAGABA) in depressive and anxiety-like phenotypes. Our findings indicate that BLAGABA neurons show dec

Huntington's Disease (HD) is a monogenic and neurodegenerative disorder cause by an abnormal amount of CAG repeats in the exon 1 of the huntingtin gene, responsible for numerous transcriptional and cellular process dysfunctions, leading to neuronal death. HD mainly targets the medium spiny neurons of the striatum and more broadly the corticostriatal pathway, but other brain areas, such as the hippocampus, are also affected at more advanced stages of the disease. These deregulations are responsible for a triad of symtoms, consisting in cognitive and psychiatric symptoms that occur prior to the