Topic: depressive-like behaviours

Dlx5/6genes encode for two homeobox transcription factors expressed in most forebrain GABAergic neurons, and involved in differentiation of Parvalbumin-positive interneurons (PV). PV interneurons are essential for normal brain function andPV expression is a hallmark of neuronal maturation. Their activity and distribution are altered in psychiatric conditions. Epidemiological studies suggest a link of the Dlx5/6locus with psychiatric disorders such as schizophrenia and autism spectrum disorder.Fluoxetine(FLX) is used to treat depression and anxiety disorders. Its administration induces a juveni

Major depression is a psychiatric disease extremely widespread and the leading cause of disability worldwide. Child abuse, defined as physical, emotional and/or sexual abuse or neglect, is considered as one of the strongest predictors of depression and suicidal behaviors. While the role of the locus-coeruleus noradrenergic system (LC-NE) in the long term effect of early life stress induced depression has been demonstrated in male, its involvement in female is lacking. The aim of this project is to better understand the contribution of LC-NE circuits in early life stress-induced depression in a