ePoster · Neuroscience
Aylina Glasenapp, Alina Ottlewski, Mesbah Alam, Christine Häger, Marcel Oelerich, Heike Bähre, Kerstin Schwabe, Marion Bankstahl · FENS Forum 2024
Carprofen is a commonly used non-steroidal anti-inflammatory analgesic, but data on pharmacokinetics and analgesic efficacy after neurosurgical interventions are limited. This study aimed to evaluate a carprofen-based analgesic regimen for craniotomies by monitoring plasma concentrations and physiological parameters.Sprague-Dawley rats (n=6) underwent subcutaneous transmitter implantation for heart rate and activity monitoring. Intracerebral 6-OHDA injection was conducted, and six weeks later depth electrodes were implanted. Oral carprofen treatment (10 mg/kg/24h) started the day prior to surg
ePoster · Neuroscience
Jan Cimbalnik, Jaromir Dolezal, Pavel Daniel, Martin Kojan, Lena Jurkovicova, Robert Roman, Wladyslaw Sredniawa, Wojciech Fortuna, Monika Sluzewska, Katarzyna Smarzewska, Peter Reinacher, Artur Weiser, Tymoteusz Skok, Tomasz Piernicki, Aleksandra Orzol, Amanda Lier, Sahar Seifzadeh, Marina Galanina, Bozena Kostek, Andrzej Czyzewski, Pawel Tabakow, Milan Brazdil, Michal Kucewicz · FENS Forum 2024
Intracranial human brain recordings from multiple stereotactically implanted depth electrodes using stereo-EEG (sEEG) technology for seizure localization provides unique local field potential signals (LFP) sampled with standard macro- and special micro-electrode contacts. Over one hundred macro- and micro-contact LFP signals localized in particular brain regions were recorded from each sEEG monitoring case as patients engaged in an automated battery of verbal memory and non-verbal gaze movement tasks. Subject eye and vocal responses in both visual and auditory task versions were automatically