Parvalbumin interneurons are related with autistic-like behaviours and altered cortical excitability in PV-Cre/Pcdh19 cKO mice
Sara Riccardi, Antonio Zippo, Daunia Laurenti, Mariaelvina Sala, Lorenzo Angelo Cingolani, Luca Murru, Maria Passafaro · FENS Forum 2024
Mutations in the X-chromosome gene PCDH19 cause Developmental and Epileptic Encephalopathy-9 (DEE9), a rare neurodevelopmental disorder characterized by epilepsy, autism spectrum disorder and cognitive impairment. DEE9 is characterized by a peculiar gender preference, affecting mainly heterozygous females.Recently, it was found that in vivo mosaic expression of Pcdh19 impairs the maturation and migration of neurons and the GABAergic circuitry, leading to defects of excitation/inhibition (E/I) balance. Since the GABAergic parvalbumin interneurons (PVIs) are powerful regulators of pyramidal neu
ePoster · Neuroscience