Topic: developmental stages

Sex and age play significant roles in spatial and contextual memory formation; however, these factors are understudied especially considering the ongoing maturation of prefrontal cortex and hippocampus through juvenility until adulthood. The receptor of Oxytocin (OXTR) has sex-dimorphic characteristics and is expressed in these regions. We previously demonstrated that blockade of prefrontal OXTR impaired extinction of contextual fear memory in juvenile females but not males (Maroun 2020). The hippocampus is central to spatial memory formation and performance in spatial memory tasks is age and

Single-cell methodologies have improved our understanding of cellular diversity within complex tissues such as the mammalian neocortex. However, despite the unprecedented granularity, sampling of minority yet diverse cell populations remains challenging. Here, we show that many subtypes of cortical inhibitory γ-aminobutyric acid-containing (GABAergic) neurons are poorly represented in current atlases, with most datasets limited to adult stages and not recapitulating cell-state transitions of these rare cell types during development. We address this gap by optimizing experimental techniques and