Topic: diagnostic biomarkers

Alzheimer’s disease (AD) is the most common and progressive type of brain disorder that affects parts of the brain responsible for memory, speaking, thinking, and many other important functions. Apart from its common risk factors such as aging, environment, and lifestyle elements, the risk of developing AD largely depends on gene variants, which present a promising opportunity for identifying novel diagnostic and therapeutic biomarkers. Early studies have revealed numerous SNPs simultaneously associated with AD and other diseases such as Parkinson’s disease, stroke, multiple sclerosis, and mor

More pilot studies are emerging with the goal of contributing to the bigger puzzle of personalized multiple sclerosis (MS) therapies. This study aimed to examine the potential benefit of using four non-coding RNAs (ncRNAs) (miR-141, miR-9, MEG3, and IFNG-AS1) as prognostic and/or diagnostic biomarkers for MS. We also aimed to examine the relationship between two single nucleotide polymorphisms (SNPs), rs547311 and rs205764 on the long intergenic non-coding RNA (linc)-00513 gene (genotyping), and the expression levels of the aforementioned genes (qPCR), in addition to IFN-g (ELISA). The diagnos