Diagnostic biomarkers

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder leading to age-associated dementia. For the first time in the last 20 years causative therapeutic strategies are on the horizon. However, since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline th

…opportunity for identifying novel diagnostic and therapeutic biomarkers. Early studies have revealed numerous SNPs simultaneously associated with AD and other diseases such as Parkinson’s disease, stroke, multiple sclerosis, and mor

…and IFNG-AS1) as prognostic and/or diagnostic biomarkers for MS. We also aimed to examine the relationship between two single nucleotide polymorphisms (SNPs), rs547311 and rs205764 on the long intergenic non-coding RNA (linc)-00513 gene (genotyping), and the expression levels of the aforementioned genes (qPCR), in addition to IFN-g (ELISA). The diagnos