Topic: directional coding

Spatial orientation deficits are emerging as very early and reliable cognitive biomarkers predicting future memory problems associated with Alzheimer’s disease, but the neural mechanisms underlying spatial disorientation have yet to be fully defined. The anterodorsal thalamic nucleus (ADn) contains a high density of head direction (HD) cells, which play a critical role in the brain's ability to create and update spatial representations, aiding in navigation and spatial memory. We propose that the accumulation of Tau filaments in cell bodies, dendrites, and axons of HD cells disrupts the proces

Control of saccadic eye movements, crucial for visual acuity during attention shifts, undergoes adaptation due to internal and external factors, such as fatigue and changing environments, critically depending on the cerebellum. Here we aim to clarify the neural mechanisms underlying saccadic adaptation in two dimensions, particularly the role of the cerebellar Purkinje cells (PC) in movement coding and plasticity. We recorded 56 PCs from the oculomotor vermis of three adult male rhesus monkeys (Macaca Mulatta) during a cross-axis adaptation task comprising three epochs. In the first pre-adapta