Disease severity

…susceptibility to infection, disease severity and treatment outcomes. The discussion focuses on mucosal immune responses, interferon signalling and their downstream effects. It brings together research at the intersection of sex biology and immunology to distinguish current understanding from unresolved questions and consider implications for infectious-disease research and treatment.

…with machine learning to estimate disease severity and seizure control. The presentations link these complementary approaches to the problem of clinical heterogeneity and assess their practical role in more individualized treatment. Sunday 6 December, 14:00–15:30 Mountain Standard Time (America/Denv

Anti-IgLON5 disease is a rare autoimmune disorder with IgLON5 autoantibodies predominantly of the IgG4 subclass. The clinical relevance of the pathogenic effects of anti-IgLON5 IgG1 and IgG4 is unclear. IgLON5-specific IgG1-4 levels were measured in 46 sera and 20 cerebrospinal fluid (CSF) samples from 13 HLA-subtyped anti-IgLON5 disease patients (6 female, 7 male) using flow cytometry. Intervals between two consecutive serum or CSF samplings were analyzed for treatment, changes of anti-IgLON5 IgG1/IgG4 levels and disease severity. Intrathecal anti-IgLON5 IgG4 synthesis (IS) was assessed. Th

…These active lesions correlated with disease severity and differed between males and female MS patients.1 Already in normal appearing white matter microglia show early signs of demyelination.5 T cells are also frequently present in advanced stages of MS and have a tissue resident memory (Trm) phenotype, are more frequently CD8+ then CD4+, are located perivascular, enriched in act