Topic: dopaminergic depletion

Electroconvulsive therapy (ECT) is a well-established treatment for psychiatric disorders. Recent reports show that ECT improves motor deficits in Parkinson's disease (PD), while the mechanism of action remains unclear. To investigate the effects of ECT in PD, we produced partial dopaminergic depletion by unilateral striatal injection of 6-OHDA. After three weeks, behavioral testing was performed using the open field and corridor test. Animals with a lateralized phenotype were randomized into ECT or sham treatment. After a two-week treatment interval with daily ECT, behavioral testing was repe

Parkinson's disease (PD) is characterized by progressive dopaminergic depletion in the striatum leading to motor deficits that often manifest with asymmetry. In this study, we investigated the role of optogenetic activation of the direct pathway in its ability to reestablish motor function and regulate oscillatory activity in cortex-basal ganglia loops. Rats received a unilateral injection of 6-OHDA into the medial forebrain bundle, followed by the delivery of adeno-associated viruses (AAVs) that specifically transduced Dopamine-1-Receptor-positive medium spiny neurons (DRD1-neurons). Using th