Topic: dorsal CA1

Memory-updating is critical in dynamic environments because updating memories with new information promotes versatility. However, little is known about how memories are updated with new information. To study how neuronal ensembles might support memory-updating, we used a hippocampus-dependent spatial reversal task to measure hippocampal ensemble dynamics when mice switched navigational goals. Using Miniscope calcium imaging, we identified neuronal ensembles (co-active neurons) in dorsal CA1 that were spatially tuned and stable across training sessions. When reward locations were moved during a

Replay, the sequential reactivation of a neuronal ensemble, is thought to play a central role in the hippocampus during the consolidation of a recent experience into a long-term memory. Following a contextual change (e.g. entering a novel environment), hippocampal place cells typically modulate their in-field firing rate and shift the position of their place field, providing a rate and place representation for the behavioral episode, respectively. However, replay has been largely defined by only the latter- based on the fidelity of sequential activity across neighboring place fields. Here we s

Synaptonuclear signalling pathways have been implicated in long term plasticity events. Nonetheless, their role in regulating cognitive behavior remains to be clarified. Here, we demonstrated that RNF10-mediated synapse-to-nucleus signaling, linking activation of synaptic NMDARs to specific transcriptional programmes in the dorsal CA1, is necessary for cognitive flexibility. In vivo RNF10 downregulation, through gene deletion and silencing, induced, specifically in CA1, alterations of both long-term potentiation and dendritic spines’ structure. At behavioral level, RNF10 downregulation suppres

Norepinephrine (NE) is one of the main neuromodulators in the brain influencing a plethora of behavioral outputs including both autonomic and cognitive functions, such as emotional learning and stress responses, through a brain-wide network of projections emanating from the Locus Coeruleus (LC). Genetically encoded indicators engineered from G-protein-coupled receptors (GPCRs) have been proven essential tools for neuroscience enabling in vivo imaging of neuromodulators with high spatiotemporal resolution. Current state-of-the-art NE sensors allow for in vivo optical detection of NE, however, t

Learning from others is one of the main expressions of humans’ social nature. Evolution has favored this capacity, conserved across species, for the environmental advantages compared to trial-and-error learning. Social group members are critical agents for the learning and development of social and prosocial behaviors. However, whether rodents can acquire prosocial behaviors through observation is not understood. Here, we used a social decision-making paradigm (SDM) in mice in which an observer can learn from a demonstrator how to share a reward with their conspecifics. Following observation,

One of the main targets of the vesicular glutamate transporter type 3 (vGluT3)-expressing median raphe neurons, is the dorsal hippocampus, a key node of the brain’s episodic memory circuit. We uncovered previously that the raphe-hippocampal glutamatergic connection selectively and highly efficiently activates certain types of hippocampal inhibitory neurons at very short latency. However, the function of this powerful inhibition-targeting modulation is still elusive. In this study, we combined the selective tagging of either vGluT3 MR neurons or their hippocampus-projecting subgroup and high-de