Topic: dorsal dentate gyrus

The dorsal dentate gyrus (dDG) plays a pivotal role in stress vulnerability and resilience. dDG granule cells interact with various interneuron subtypes, forming a complex local circuit essential for stress processing. Studies have shown differential activity in specific interneuron subtypes in response to stress, impacting coping mechanisms.This study examines the impact of two distinct categories of DG interneurons, chandelier and basket cells, on coping behavior. Ephrin A7 (EphA7) stabilizes synaptic terminals in basket cells, while Neurofascin (NF) facilitates axo-axonic synapse formation

Recent evidence suggests that epigenetic mechanisms may contribute to memory deficits in aging. Specifically, in the hippocampus, the repressive epigenetic mark H3K9me3 (tri-methylated lysine 9 on histone H3) has been implicated in the silencing of genes essential for memory. Yet, the impact of the age-related increased H3K9me3 levels on neuronal function remains unclear. We hypothesized that H3K9me3 accumulation renders neurons refractory to stimulation. To assess the influence of H3K9me3 on neuronal activation, we reduced H3K9me3 levels by silencing the major methyltransferase responsible to