Topic: dorsal pallium

Astrocytes constitute a heterogeneous population of cells in terms of function and morphology. Although several embryonic sources of cortical astrocytes have been reported, cortical progenitors located from the dorsal pallium are considered their main production site. However, the potential link between the heterogeneity of cortical astrocytes and their developmental origin remains elusive. Recently, we identified a new embryonic source for cortical protoplasmic astrocytes located outside of the dorsal pallium, in a restricted domain containing Aldh1L1-expressing cells. In order to further cha

In all metazoans, neural circuit function is subject to regulation by state-specific neuromodulation. Here, we mapped the expression of neuromodulatory systems in the zebrafish telencephalon to ultimately understand their contributions to memory formation. We first generated a comprehensive single-cell RNA sequencing dataset of the telencephalon of adult zebrafish and mapped the diversity of neuronal cell types to anatomical brain areas. Gene expression data of G-protein coupled receptors were mined to embed individual cell types in neuromodulatory networks, allowing inference about which modu