Topic: Dorsal Raphe Nuclei

Fear learning and extinction are crucial for survival and lead to disease, if impaired. Recently, it has been demonstrated that the cerebellum is bidirectionally controlling fear learning via the fastigial nucleus (FN) to ventrolateral periaqueductal grey (vlPAG) pathway in rodents (Frontera et al., 2020, Lawrenson et al., 2022). The mechanisms of the cerebellar influence on fear learning still need to be elucidated. Using a combined anterograde/retrograde viral tracing strategy, we targeted a dorsal raphe nuclei (DRN)/vlPAG pathway that projects on the FN. In extracellular recordings during a

Aims: The identification of peripheral biomarkers of brain dysfunctions is essential to aid diagnosis and facilitate patient stratification. MicroRNAs are excellent candidate molecules to this purpose, as they can be expressed in the brain with regional and functional specificity, and they are highly stable in blood serum, unlike other RNA transcripts. Mir-34a is expressed with high specificity in a subpopulation of GABAergic neurons within the mouse Dorsal Raphe Nuclei (DRN), where it regulates GABAergic transmission in response to aversive stimuli. However, a direct connection between the br