Topic: dorsal tegmental nucleus

Spatial orientation depends on the integration of different sensory streams by the gead direction circuit (HD). Previous work has demonstrated that the generation of the head direction signal critically depends on the integrity of angular head velocity (AHV) signals largely provided by the vestibular system. From the vestibular periphery, angular vestibular signal is processed by several cerebellar and brainstem relays including the medial vestibular nuclei (mVN), the prepositus hypoglossi nucleus (nPH), the supragenual nucleus (SG) and the dorsal tegmental nucleus (DTN). While several electro

The vestibular system plays a pivotal role in tracking head direction for effective navigation in complex environments. We hypothesize that the decline in navigational ability observed with aging is closely linked to the deterioration of a key ascending vestibular pathway in the head-direction network. With cre-dependent viruses for both anterograde and retrograde tracings, we discovered in mice a previously unreported direct pathway from the medial vestibular nucleus (MVN) to the dorsal tegmental nucleus (DTN), supplementing the conventional indirect pathways via the nucleus prepositus hypogl