Topic: dorso-medial prefrontal cortex

Associative learning is crucial for adapting to environmental changes. Interactions among neuronal populations involving the dorso-medial prefrontal cortex (dmPFC) in rodents are proposed to regulate associative memory. However, how these neuronal populations store and process information about the association remains unclear. Here we developed a pipeline for longitudinal two-photon imaging and computational dissection of neural population activities in male mouse dmPFC during fear-conditioning procedures, enabling us to detect learning-dependent changes in the dmPFC network topology. After co

Survival critically depends on the ability to detect threatening situations and in further selecting appropriate defensive behavior. This crucial mechanism contributed by contextual discrimination largely depends on the continuous evaluation of sensory cues that define the context. However, it may give rise to anxiety-related psychological disorders in situations of inaccurate context processing. We here aim to characterize neuronal determinants that allow the encoding and consolidation of contextual fear memory to successfully drive behavioral adaption, and mechanisms that especially induce c