Topic: dorsolateral geniculate nucleus

The dorsolateral geniculate nucleus (dLGN) of the thalamus is an essential processing stage for retinal signals to reach the primary visual cortex (V1). How these feedforward signals are modulated by corticothalamic (CT) feedback and behavior remains an open question. To quantify how feedforward, feedback and behavior combine in shaping dLGN responses, direct and selective control of CT feedback in behaving animals is needed, as well as a computational model that takes the various contributing factors into account. We here recorded extracellular responses in dLGN of awake mice to a rich, dynam

Traditionally, the dorsolateral geniculate nucleus (dLGN) of the thalamus has been considered a feedforward relay station for retinal signals to reach primary visual cortex. The local and long-range circuits of dLGN, however, suggest that this view is not correct. Indeed, besides the thalamo-cortical relay cells, dLGN contains local inhibitory interneurons, and receives not only feedforward input from the retina, but also massive direct and indirect feedback from primary visual cortex. Furthermore, it is one of the earliest processing stages in the visual system that integrates visual informat