Topic: dorsolateral PFC

Down-regulating emotional overreactions toward threats is fundamental for developing treatments for anxiety and post-traumatic disorders. The prefrontal cortex (PFC) is critical for top-down modulatory processes, and despite previous studies adopting repetitive Transcranial Magnetic Stimulation (rTMS) over this region provided encouraging results in enhancing extinction, no studies have hitherto explored the effects of stimulating the medial anterior PFC (aPFC, encompassing the Brodmann area 10) on threat memory and generalization. In this study, we aimed to test an rTMS procedure over the aPF

The prefrontal cortex (PFC) has been reported to play a key role in higher-order cognitive functions by dynamically adjusting its firing activity. Here, we studied the specific contributions of two cell subclasses, putative excitatory pyramidal (68%) and putative inhibitory interneurons (24%), within a sample of 147 single units recorded from the dorsolateral PFC of two macaque monkeys while they performed a Transitive Inference (TI) task. The TI task required learning the relationship between the adjacent items of an arbitrarily rank-ordered sequence in every session, i.e., A>B>C>D&g