Topic: dorsomedial hypothalamus

The preoptic area (POA) of the hypothalamus has garnered attention regarding its pivotal role in energy balance control and thermoregulation. Activation or inhibition of specific POA neurons has been shown to affect body temperature, locomotor activity and energy expenditure. To gain novel insights into this regulatory mechanism, we have conducted a comprehensive analysis of a distinct neuronal cluster within the POA that express the neuropeptide prepronociceptin (PNOC). Using chemogenetic techniques, we selectively activated PNOC(POA) neurons of mice and observed a significant reduction in br

Thermogenesis is a vital physiological process that contributes to maintaining energy homeostasis, metabolic health, and adaptation to environmental changes. Central for metabolic regulation is the hypothalamus, orchestrating a diverse array of neuroendocrine systems. Within this intricate network, the role of thyrotropin-releasing hormone (TRH) neurons of the hypothalamus is unknown. Our project aimed to delineate TRH populations implicated in modulating brown adipose tissue (BAT)-derived thermogenesis. Employing an exploratory approach utilizing retrograde tracers from BAT, we pinpointed thr

Stroke is a preeminent contributor of the global burden of diseases. Hypothermia, among other therapeutic approaches, has been proposed to promote neural survival after stroke, yet the physiological cooling remains ineffective and induces collateral side effects. The thermoregulatory mechanisms are under the control of neuronal identities that connect peripheral signals of the central nervous system, which are predominantly conveyed into the hypothalamus. Here, we aimed to identify a thermoregulatory neuronal subpopulation located at the dorsomedial hypothalamus (DMH) and investigate the DMH-p