Topic: doublecortin (DCX)

The entorhinal cortex lesion is a validated model for studying neuronal, dendritic and spine remodelling of dentate gyrus granule cells after denervation. Our research aims to investigate the effect of the layer-selective denervation of the dentate gyrus on the proliferation and differentiation of neurons in the granule cell layer, as the mechanisms that drive the remodelling due to the loss of input are not yet understood. Therefore, in anaesthetised adult male C57Bl/6 mice, the transection of the perforant pathway was performed, resulting in the layer-specific denervation of dentate granule

Methamphetamine (MA) is one of the most abused illicit drugs in the world. The abuse of this drug among adolescents is problematic due to the still developing physiological functions of the body, including the central nervous system (CNS). The hippocampus (HP) is a part of the limbic system that is associated with cognition, as well as the reward system, which is mediated by dopamine (DA). Disruption of this system is the basic mechanism underlying addiction and results in cognition deficiencies.In this work, we focused on the influence of MA on the development of the HP during postnatal days

In the developing hippocampus, once generated, the pyramidal neurons migrate along radial glia processes to form the complex CA regions. Therefore, it is critical to understand the mechanisms controlling neuronal motility, leading to coordinated neuronal function. Doublecortin (DCX) shows mutations in human lissencephaly and heterotopia associated with epilepsy and intellectual disability. In the Dcx mouse mutant, the CA3 pyramidal region in the hippocampus forms an abnormal double layer, typical of heterotopia. Consequently, the mutant mouse presents an increased susceptibility to epilepsy. S