Topic: Drd1

Focal Cortical Dysplasia IIB (FCDIIB) represents a large variety of cortical malformations associated with abnormal cortical layering and appearance of dysmorphic neuronal elements, often occurring in the frontal cortex. FCDIIB is a common cause of pharmaco-resistant epilepsies and altered local neuronal activity has been reported in human FCDIIB tissue samples. Local cortical microcircuits are extensively modulated by monoaminergic axonal projections arising from the brain stem. Previous analysis of monoaminergic modulatory inputs in human FCDIIB biopsies suggested altered density and distrib

Cocaine and sugar act as appetitive stimuli, engaging the brain's dopaminergic system to induce positive experiences. While both substances trigger dopamine release, cocaine additionally blocks its reuptake. Dopamine-sensitive neurons, particularly those expressing DRD1 or DRD2, play a pivotal role in mediating these effects. Such cells were recently discovered in the Central Amygdala (CeA), a brain region involved in regulating various emotions, both aversive and appetitive. Given the limited research on the role of dopamine in this brain region, we studied the activity of dopamine-sensitive

The ketogenic diet (KD) is known to reduce ethanol consumption in non-stress conditions (Blanco-Gandía et al. 2021). Therefore, our objective was to assess whether KD modifies stress-induced changes in gene expression and ethanol consumption in female mice. 64 female OF1 mice were categorized into four groups based on the administered diet (KD vs. Standard Diet, STD) and exposure to stress (Vicarious Social Defeat sessions, VSD, vs. Exploration sessions, EXP): STD-EXP (n=16), STD-VSD (n=16), KD-EXP (n=16), and KD-VSD (n=16). The KD-fed mice remained in ketosis from adolescence until the final