What about antibiotics for the treatment of the dyskinesia induced by L-DOPA?
Elaine Del-Bel · Professor of Physiology,Department of Morphology, Physiology and Basic Pathology, School of Dentistry, Ribeirão Preto (FORP), University of São Paulo.
Mon, Dec 14, 2020 · 06:00 UTC
L-DOPA-induced dyskinesia is a debilitating adverse effect of treating Parkinson’s disease with this drug. New therapeutic approaches that prevent or attenuate this side effect is clearly needed. Wistar adult male rats submitted to 6-hydroxydopamine-induced unilateral medial forebrain bundle lesions were treated with L-DOPA (oral or subcutaneous, 20 mg kg-1) once a day for 14 days. After this period, we tested if doxycycline (40 mg kg-1, intraperitoneal, a subantimicrobial dose) and COL-3 (50 and 100 nmol, intracerebroventricular) could reverse LID. In an additional experiment, doxycycline was