Topic: early life maternal separation

Early life stress (ELS) due to neglect or abuse, has profound and lasting effects on adult neural function, contributing to various psychopathologies. Utilizing the well-established model of early life maternal separation (ELMS), this study investigated the impact of ELS on adult behavior. For the maternally separated (MS+) group, pups were separated from their mother for 3 hours from postnatal day 1 to 14, while control (stress naive) group pups remained in their home cages. Behavioral assessments from week 8-10 (young adults) revealed significant differences between MS+ and control mice. Bot

Emerging studies have demonstrated that neural-immune interactions play a critical role in gastrointestinal diseases. Sympathetic neural system (SNS) activity, susceptible to stress modulation, has been elucidated for its direct impact on immune cells through adrenergic receptors, or alternatively, its indirect influence via the modulation of proinflammatory chemical release. However, sympathetic neural-immune interactions in the gastrointestinal tract and their contribution to visceral pain are still unclear. Here, we established an early life stress model with gastrointestinal disorder. In t