Topic: Earth Mover’s Distance

Temporal sequences are an important feature of neural information processing in biology. Neurons can fire a spike with millisecond precision, and, at the network level, repetitions of spatiotemporal spike patterns are observed in neurobiological data. However, methods for detecting precise temporal patterns in neural activity suffer from high computational complexity and poor robustness to noise, and quantitative detection of these repetitive patterns remains an open problem. Here, we propose a new method to extract spike patterns embedded in raster plots using a 1D convolutional autoencoder w

Pathological amyloid beta (Aβ) accumulation in the brain has been associated with poor cognitive performance and aberrant neuronal activity in preclinical mouse models of Alzheimer’s disease (AD). Here, we assessed the impact of advanced Aβ pathology on spatial information processing in the medial entorhinal cortex (MEC) of 18-month APP NL-G-F knock-in mice as they explored contextually novel and familiar open field arenas in a two-day, four-session recording paradigm. Using in vivo electrophysiology, we tracked single-units across all sessions and found that MEC single-unit spatial informatio