Topic: egocentric vector coding

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by deficits in episodic memory processing and spatial navigation. Especially, the egocentric neural representation of space, which is important for constructing an egocentric cognitive map, is essential for spatial navigation. However, how spatial navigation deficits relate to egocentric neural representation of space remains unclear. The retrosplenial cortex (RSC) is one of the regions affected by amyloidosis in the early stages of AD and is well known for its role in egocentric spatial representation. Specifically, it cont

Efficient spatial navigation in complex environments relies on the construction of an egocentric cognitive map. Recent studies have reported that subpopulations of excitatory neurons in the granular retrosplenial cortex (RSC) are selectively activated at specific distances and orientations relative to environmental boundaries and vertices, tuned by the heading directions of the animal, to perform egocentric vector coding of the environmental geometry. However, the neural circuit mechanisms explaining how egocentric representation of vertices and boundaries emerges are yet unknown. One possible