Topic: electrode arrays

Brain networks have the remarkable ability to adapt to neuron loss; however, little is known about how population spiking activity is affected quantitatively and even less is known about how populations adapt to restore behavior. Here, we analyzed the impact of neuron loss on population correlation structure using numerical simulations, a spiking neural network model, and in vivo spiking data from a lesion technique in which focal neuron loss is created through chronically implanted electrode arrays in awake-behaving animals. This easily-repeated perturbation allows neuroscientists to track t

Spinal cord stimulation is a promising therapy for the recovery after spinal cord injury and control of movement. However, the complex interaction between electrodes and neural reaction impedes more effective neuromodulation. Empirical knowledge and manual adjustment are playing dominant role for the tuning of neuromodulation parameters. The growth of electrode array’s complexity also brings new challenges to find optimal stimulating configurations. Developing a more efficient way to predict the stimulation results and explore the optimal therapy is necessary for the tuning of sensitive neural