Topic: endosomal trafficking

Maintaining the delicate balance between excitatory and inhibitory synaptic activity is crucial for proper brain function. The endosomal trafficking complex, retromer, plays a pivotal role in synaptic function by regulating the post-endocytic sorting of a variety of integral proteins at both excitatory and inhibitory synapses. As a result, SNX27/retromer is emerging as a potential mediator of excitatory/inhibitory crosstalk. In surface proteomic screens from primary cultured neurons, we have shown that a variety of subunits of γ-aminobutyric acid receptors (GABAARs) exhibit reduced surface exp

RNA localization is particularly important in morphologically complex cells such as neurons, where precise protein expression is necessary to achieve highly compartmentalized functions. Emerging evidence suggests that endosomal trafficking could be directly involved in RNA localization and translation in neurons. However, the identity of endosomal-regulated mRNAs, and the functional role of endosomes in controlling subcellular protein synthesis, remain to be understood. By coupling proximity labeling and RNA sequencing, we here report the presence of a rich repertoire of mRNAs associated with

Synaptic dysfunction is an early hallmark of AD pathology. It is characterized by the disruption of synaptic transmission and plasticity. Endosomal trafficking is central to this process. The retromer complex orchestrates the movement of vesicle contents, either pushing them back to the Golgi, degrading them, or recycling them to the plasma membrane. Variations in the cargo recognition component of the retromer, VPS35, have been associated with both Parkinson's (D620N mutation, PARK17) and Alzheimer's (L625P mutation). Extensive pathophysiological studies have been conducted on Parkinson's dis