Topic: entopeduncular nucleus

Aims: Dystonia is a neurological syndrome that alters voluntary muscle control and sustained posture. The most promising targets for deep brain stimulation (DBS) are the subthalamic nucleus or Globus Pallidus internus (GPi). DBS has shown compelling therapeutic advantages in many individuals with primary generalized/segmental dystonia. However, the mechanisms of DBS still need to be clarified. In this context, we were interested in the impact of pallidal DBS on cerebellar activity. Methods: We investigated this topic using a model of primary paroxysmal dystonia (dtsz hamster, 2 months old), im

The entopeduncular nucleus EP, one of the basal ganglia(BGs), is considered one of the essential output nuclei, sending synapses belonging to the pathways essential for normal motor activity to two specific regions in the ventral lateral thalamic nuclei(VL) and ventral anterior thalamic nuclei(VA).The basal ganglia innervate the thalamus through 3 pathways:direct, indirect, and hyper-direct.By these three pathways, we get an innervation that causes disinhibition or inhibition of the thalamus.The research aimed to study the thalamus, the relay center for transmitting information received from m

Non-motor symptoms, such as sleep problems, often precede motor symptoms in patients with Parkinson’s Disease (PD). Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is used to control motor fluctuations of PD and there is increasing evidence that STN-DBS improves patients’ subjective sleep quality. However, how and if the STN regulates the sleep-wake cycle is unknown. We recorded activity of Vglut2-neurons in the STN during mice’s inactive period (lights on) and found peak calcium signals increased when mice transitioned from NREM to wake (p<0.05) and from NREM to REM (p<0.0