Topic: epidural electrical stimulation

Spinal neuromodulation via epidural electrical stimulation is a promising therapy for motor function restoration of patients with spinal cord injury. By applying specific sequences of electrical stimulation to the spinal cord through the electrode array, the patient can achieve multiple movements. However, one of main difficulties of this therapy is that the mapping between stimulation parameters and body motions is complex and ambiguous. To achieve specific actions, it often requires a large number of experiments to tune stimulation parameters. Individual differences of functional in

Neurological diseases such as Multiple System Atrophy (MSA), Parkinson's disease, Lewy Body Dementia, and Pure Autonomic Failure lead to severe dysfunctions of the autonomic nervous system, resulting in neurogenic orthostatic hypotension. Current treatments remain limited, and certain therapies, such as dopamine replacement, may worsen symptoms. Our recent research revealed how a neuroprosthetic intervention such as epidural electrical stimulation (EES) of the thoracic spinal cord regulates blood pressure, leading to the development of a neuroprosthetic baroreflex effective across multiple spe

Epidural Electrical Stimulation (EES) of the spinal cord is a promising therapy that has alleviated gait deficits in animal models and patients with Parkinson's disease (PD). Here, we hypothesised that closed-loop stimulation - targeted to specific phases of cortical oscillations - can refine the interaction of EES with pathological network states. For this, we tailored a real-time system that tracks a selected frequency and used it to deliver stimulation pulses timed to ECOG signals from M2 cortex. We tested the stimulation platform in the unilateral 6-OHDA PD rat model, that resulted in modu