Topic: ERK

The migratory dynamics of macrophages are pivotal in orchestrating inflammation and the progression of pathological states. This study delves into the therapeutic promise of morin hydrate (MH), a bioflavonoid ubiquitously present in diverse botanical sources, aiming to assuage inflammation through the nuanced inhibition of macrophage migration. Employing the LPS-stimulated RAW264.7 cell line, the specific molecular mechanisms underpinning MH's anti-inflammatory prowess are scrutinized. The findings unveil that MH manifests concentration-dependent anti-inflammatory effects, intricately curtaili

Group I metabotropic glutamate receptors (mGluR) are involved in various forms of synaptic plasticity that underlie declarative memory by inducing long-term depression (mGluR-LTD). mGLUR-LTD results from an endocytosis of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) underlying synaptic depression. The lab has previously shown that mGluR5 specifically activates TRPC1 channel, a Transient Receptor Potential channel that is highly expressed in CA1-3 regions of the hippocampus.To investigate the role of mGluR-TRPC1 in synaptic plasticity, and to decipher its downstre

Opiates addiction is a major public health problem worldwide. This condition has been conventionally considered to be a consequence of the neuronal activation of classical opioid receptors. However, nowadays numerous studies point out to the TLR4 signaling pathway as a target for opiates and its participation, through the modulation of neuroinflammatory mechanisms, in many of these drugs’ effects has been postulated. Thus, glial cells are currently the focus of a number of studies in order to understand their contribution to the addictive properties of opiates, as they have the ability to modu

Sleep is essential for memory formation and consolidation, and sleep loss is associated with cognitive decline. The CA2 subregion of the hippocampus is involved in social memory and plays a critical role in altering brain activity and memory performance. Despite the crucial role of hippocampal CA2 in memory, how sleep influences social memory remains relatively unexplored. Our aim was to investigate whether and how sleep loss influences the CA2 region in terms of synaptic plasticity and social memory in mice. We conducted field electrophysiology, Western blot analysis, and behavioral studies.