Topic: ethanol consumption

Social stress increases susceptibility to develop substance use disorders, which can be modulated by intermittent exposure to a high-fat diet (HFD). However, both HFD and stress can elevate neuroinflammation levels under specific conditions. The objective of this study was to assess the protective role of intermittent exposure to HFD on the increase in ethanol consumption induced by social stress. The neuroinflammatory response in the hippocampus and the striatum was evaluated by quantitative real-time PCR of several gene expressions. Adult male OF1 mice were exposed to the repeated social def

The ketogenic diet (KD) is known to reduce ethanol consumption in non-stress conditions (Blanco-Gandía et al. 2021). Therefore, our objective was to assess whether KD modifies stress-induced changes in gene expression and ethanol consumption in female mice. 64 female OF1 mice were categorized into four groups based on the administered diet (KD vs. Standard Diet, STD) and exposure to stress (Vicarious Social Defeat sessions, VSD, vs. Exploration sessions, EXP): STD-EXP (n=16), STD-VSD (n=16), KD-EXP (n=16), and KD-VSD (n=16). The KD-fed mice remained in ketosis from adolescence until the final