Topic: ethosuximide

The default mode network`s (DMN) can be investigated using default EEG reactivity (DER).The default oscillatory macrostate (DEM) is exemplified by the macrostate showing thehighest decrease in occurrence probability during intermittent photic stimulation (IPS).This study aimed to investigate DER, in the deeply sedated epileptic brain.We used a genetic rat model of absence epilepsy, the adult Wistar Albino Glaxo Rijwijk(WAG/Rij) rat. Controls consisted of age-matched Wistar rats.Deep aesthetic coma was induced by chloral hydrate. We performed cortical EEG recordingsduring the induced altered st

Aims: Survivors of cerebral malaria (CM) might develop lifelong sequelae such as cognitive deficits, altered behaviour or epilepsy. Animal models are needed to understand the underlying pathophysiology and to develop preventive or ameliorating therapies. Therefore, in this study we aimed to establish a mouse model reflecting consequences of CM. Methods: To ensure survival, C57BL/6 mice infected with P. berghei ANKA (PbANKA) were closely monitored for parasitaemia and clinical signs of CM, and rescued by artesunate treatment. Following electrode implantation, repetitive EEG-video monitoring was

Altered Neuregulin1 (NRG1) expression and NRG1/ErbB4 signaling are implicated in schizophrenia and temporal lobe epilepsy pathogenesis, however limited research has been done with respect to their role in epilepsy. Our study on HA-Nrg1-tg mice that overexpress the cysteine-rich domain of NRG1-type III, revealed diverse recurrent epileptic seizures characterized by spike and wave discharges (SWDs) in the cortex and thalamus. Seizure expression varied among animals, with slow (4 – 5 Hz) and/or fast (6 - 8 Hz) SWDs present. Slow 4-5 Hz SWDs occurred during passive wakefulness and were abundant du