Using evolutionary algorithms to explore single-cell heterogeneity and microcircuit operation in the hippocampus
Andrea Navas-Olive · Instituto Cajal CSIC
Sun, Jul 19, 2020 · 17:40 UTC
The hippocampus-entorhinal system is critical for learning and memory. Recent cutting-edge single-cell technologies from RNAseq to electrophysiology are disclosing a so far unrecognized heterogeneity within the major cell types (1). Surprisingly, massive high-throughput recordings of these very same cells identify low dimensional microcircuit dynamics (2,3). Reconciling both views is critical to understand how the brain operates. " "The CA1 region is considered high in the hierarchy of the entorhinal-hippocampal system. Traditionally viewed as a single layered structure, recent evidence has di