Topic: excitation–inhibition ratio

It is well known that the state of hunger can modulate hormones and hypothalamic neural circuits to drive food-seeking behavior and consumption. While the olfactory sense is critical to foraging, the role of the olfactory cortex in regulating food learning and preference is unclear. The anterior piriform cortex (APC) is located one synapse downstream of the olfactory bulb and is an important olfactory structure for odor discrimination, perception, and memory. Here, we investigated whether acute fasting in mice can alter an odor-guided foraging behavior and how it can alter neurons and synapses