Topic: excitatory/inhibitory imbalance

Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily affecting females, characterised by the loss of motor skills and behavioural abnormalities linked to an excitatory/inhibitory imbalance involving GABA dysfunction. GABAergic deficits, particularly in somatostatin (SST) interneurons, play a crucial role in RTT pathophysiology and have been successfully replicated in mouse models. This study delves deeper into understanding the role of GABAergic interneuron inhibition in an RTT mouse model. Neonatal injections were administered to Mecp2tm1.1Bird x Sst-IRES-Cre mice at P1,

Maternal obesity during pregnancy is a significant global health concern, impacting the metabolic, cardiovascular, and neurological health of the offspring, the latter being a research topic that has become of great interest. Our study investigates their effects on cognition, focusing on the hippocampus, a region vulnerable to prenatal insults. While maternal high-fat diet (mHFD) has been linked to cognitive deficits and hippocampal changes, its impact on synaptic transmission remains unexplored.Our focus was to understand how this adverse prenatal environment influences memory processes and w